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KMID : 0365819910310020057
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Journal of Pusan Medical College
1991 Volume.31 No. 2 p.57 ~ p.64
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Na^(+)-K^(+) pump of Red Blood Cells in Patients with Essential Hypertension
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Abstract
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In order to investigate the changes of Na+ transport system of the red blood cells in the patients with essential hypertension, Na´-K+ pump activity was measured in 30 cases of essential hypertension and 20 healthy normal controls. Furthermore, these measurements were analyzed in terms of some important clinical parameters in the patients with essential hypertension, i.e., body mass index(BMI), status of hypertension, and plasma lipids.
Na´ and K+ contents of red cells in hypertensive patients were 16.9± 1.4 and 77.8± 2.1 mmol/L cells, respectively, and no significant difference was found compared with respective values of normal control(142± 0. 9 and 82.8± 2.8 mmol/L cells).
Na+-K+ pump activity showed a significant depression(&72± 0.80 and 12.79± 0.52 μmol Pi/mg hr) in the patients group compared with controls.
In the analysis regarding the relationship between Na+ transport system and some important clinical parameters of the patients with essential hypertension, Na+-K+ pump activity was related to the level of total cholesterol or triglyceride. But the level of blood pressure did not show a significant relationship with the Na+ transport system.
These results suggest that Na+ transport systems in essential hypertenive patients were significantly altered compared with normal healthy controls, but these were overlapped between some of two groups. Thus further studies are required to clarify whether abnormalities of the Na´ transport systems in red blood cells are involved in the pathogenesis of essential hypertension.
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